– Schwabe News
Syzygium jambolanum and Cephalandra indica are used in homoeopathy for treatment of type-2 diabetes. However, the molecular mechanisms responsible for such effects are not known. Authors of this study have used homoeopathic preparations of S. jambolanum and C. indica in mother tincture, 6c and 30c to examine the molecular mechanism of antidiabetic effects in the skeletal muscle of rats with high fat and fructose-induced type-2 diabetes mellitus. After 30 days treatment, fasting blood glucose, serum insulin and insulin signaling molecules in the skeletal muscle (gastrocnemius) were measured. Diabetic rats showed a significant decrease in serum insulin and lipid profile as well as low levels of insulin receptor (IR), v-akt murine thymoma viral oncogene homolog (Akt), p-Aktser473 and glucose transporter-4 (GLUT4) protein expression (p < 0.05) with a significant increase in fasting blood glucose level (p < 0.05) compared to the control group. Treatment with homoeopathic remedies significantly increased the serum insulin and expression of these proteins (p < 0.05) with a significant decrease in fasting blood glucose (p < 0.05) compared to diabetic rats.
The authors have concluded that in the present study homoeopathic preparations of S. jambolanum and C. indica, including ultramolecular dilutions exhibit antidiabetic effects, improving insulin action through activation of insulin signaling molecules in skeletal muscle of type-2 diabetic rats.
Reference: Sathish Sampath, Akilavalli Narasimhan, Raveendar Chinta, K.R. Janardanan Nair, Anil Khurana, Debadatta Nayak, Alok Kumar, Balasubramanian Karundevi, Effect of homoeopathic preparations of Syzygium jambolanum and Cephalandra indica on gastrocnemius muscle of high fat and high fructose-induced type-2 diabetic rats, Homeopathy, Volume 102, Issue 3 , Pages 160-171, July 2013
– Schwabe News